Toyopearl GigaCap S-650 media is a high capacity cation exchange resin* optimized specifically for the capture and purification of IgG. Toyopearl HW-65 resin is the polymeric base bead chemically modified to provide a high level of cationic binding sites for IgG. It exhibits typical dynamic binding capacities in the vicinity of 140 g/L for IgG. This new polymer product is stable at high linear velocities, has good pressure flow characteristics and will withstand back pressures up to 3 MPa. The new higher capacity and back pressure stability of Toyopearl GigaCap S-650  resin creates opportunities for increased throughput in downstream cation exchange purification steps.

While Toyopearl GigaCap S-650 media was specifically optimized for IgG, it also exhibits high binding capacities for smaller proteins. Typical dynamic binding capacities for lysozyme are in excess of 160 g/L.

Toyopearl GigaCap S-650M media also has excellent base stability in 1.0mol/L NaOH and shows robust clean in place properties with minimal loss of capacity after 50 X 1 hour cycles of caustic exposure also using 1.0mol/L NaOH. (data)

*specifically designed for packed bed use 

Structure:

Product Attributes:

Pore size (mean):  100nm  Particle size (mean):  75µm (M-grade)   Pressure rating:  0.3 MPa  Shipping buffer:  20% ethanol  pH stability:  3-13

Literature:

Operating Conditions and Specifications
 

 

P/N Description Resin volume Particle size   0021833 Toyopearl GigaCap S-650M 100mL 50-100µm   0021834 Toyopearl GigaCap S-650M 250mL 50-100µm   0021835 Toyopearl GigaCap S-650M 1L 50-100µm   0021836 Toyopearl GigaCap S-650M 5L 50-100µm   0021868 ToyoScreen GigaCap S-650M 1mL x 6 ea. 50-100µm   0021869 ToyoScreen GigaCap S-650M 5mL x 6 ea. 50-100µm