TOYOPEARL Butyl-600 resin has the second highest hydrophobicity of the HIC ligands offered by Tosoh Bioscience. Its pore size is between that of TOYOPEARL Butyl-650 and TOYOPEARL SuperButyl-550 media. It has been optimized for the purification of monoclonal antibodies and is typically used as an intermediate purification or polishing step.

To see other products optimized for HIC purification of mAbs please see TOYOPEARL PPG-600 and TOYOPEARL Phenyl-600 medias.


Ether < PPG < Phenyl < Butyl < Hexyl

Selectivities of TOYOPEARL HIC Resins

Typical Dynamic Binding Capacities for Humanized mAb


Comparison of TOYOPEARL 600M Series HIC Resins

Literature :

 • Catalog

 • Instruction Manual