TOYOPEARL GigaCap CM-650 media is a high capacity cation exchange resin* optimized specifically for high throughput purification of IgG. TOYOPEARL HW-65 resin is the polymeric base bead, which is chemically modified to provide a high level of cationic binding sites for IgG. It exhibits typical dynamic binding capacities in the vicinity of 100 g/L for IgG. This new polymer product is stable at high linear velocities, has good pressure flow characteristics and will withstand back pressures up to 0.3 MPa. The new higher capacity and back pressure stability of TOYOPEARL GigaCap CM-650 resin creates opportunities for increased throughput in downstream cation exchange purification steps.

TOYOPEARL GigaCap CM-650 resin has a different selectivity than TOYOPEARL GigaCap S-650 resin. With its unusually high capacity for a weak cationic exchange resin this selectivity may be exploited for either mAb or traditional protein purifications.

TOYOPEARL GigaCap CM-650 media also has excellent base stability in 0.5 mol/L NaOH.

* TOYOPEARL GigaCap resins are specifically designed for packed bed use.


IgG breakthrough curves


Pressure flow properties

Literature :

 • Catalog

 • Instruction Manual